Te tikanga me te whakahaere whiriwhiri o te trifluoromethylation o ngā rauropi kore utu
He mea nui te mahi a te trifluoromethylation rauropi kore utu i roto i te hanganga rauropi, inā koa i raro i ngā āhuatanga o te parahi/whakaataata, e whakaatu ana te tauhohenga i te mahi ahurei me te whiriwhiri. He mea nui te ako hohonu i tana tikanga tauhohenga me te rautaki whakahaere whiriwhiri hei whakawhānui ake i te whānuitanga o te tono o te tauhohenga trifluoromethylation me te whakatutuki i te hanganga rauropi tika.
I roto i te tauhohenga trifluoromethylation rauropi kore utu i whakakorikoria e te parahi, ka whakamahia te tote parahi hei whakakorikori hei whakatutuki i te whakaputanga me te whakawhiti i te rauropi kore utu trifluoromethyl mā te huringa redox. I roto i te tukanga tauhohenga, ka whakakorikoria te tote parahi (I) me te matū trifluoromethylation ka tāpirihia hei hanga i te takawaenga parahi (III) - trifluoromethyl, kātahi ka pakaru te takawaenga hei tuku i te rauropi trifluoromethyl. Ka tauhohe te rauropi kore utu ki te ngota matū hei hanga i te takawaenga rauropi kore utu waro trifluoromethyl. Hei whakamutunga, ka oti te huringa whakakorikori mā te whakaiti i te tote parahi (II). Mā te whakarerekē i te momo tote parahi, te hanganga ligand me ngā āhuatanga tauhohenga, ka taea te whakahaere pai i te whiriwhiringa o te tauhohenga, ā, ka taea te whakatutuki i te trifluoromethylation o ngā matū rerekē.
Ko te tauhohenga trifluoromethylation radical kore utu photocatalytic e whakamahi ana i ngā takirua pū irahiko i hangaia i muri i te mimiti o ngā photon e te photocatalyst hei tīmata i te hanganga o ngā radical kore utu trifluoromethyl. I raro i te hihi mārama e kitea ana, ka whakaohohia te photocatalyst, ā, ka whakaitihia e ngā irahiko i hangaia te matū trifluoromethylation ki ngā radical kore utu trifluoromethyl, i te mea ka waikurahia e ngā pū ngā ngota substrate hei hanga i ngā kationa radical kore utu. Mā te hoahoa tika i te hanganga o te photocatalyst me te whiriwhiri i te whakarewa tauhohenga tika, ka taea te whakahaere i te whiriwhiringa tauhohenga. Hei tāpiri, mā te whakaurunga o ngā rōpū ārahi, te whakamahi rānei i ngā catalyst chiral ka taea hoki te whakatutuki i te enantioselective, regioselective rānei free radical trifluoromethylation, e whakarato ana i tētahi tikanga hou mō te hanga i ngā pūhui trifluoromethyl chiral. Mā te rangahau hohonu o te tikanga tauhohenga me te whakahaere whiriwhiringa o te trifluoromethylation radical kore utu, ka nui ake te mahi a te tauhohenga i roto i te mara o te hanga rauropi.